Resigned Director: ASTRA PHARMACEUTICALS LIMITED - Active (   From: Oct-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AVLEX LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: R&Q ALPHA COMPANY PLC - Converted / closed (   From: Mar-2009   To: Sep-2015  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: CARE LABORATORIES LIMITED. - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENECA PHARMACEUTICALS (NUMBER 2) LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAPHARM - Active (   From: Oct-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: CARE PRODUCTS LIMITED. - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO. 12) LIMITED - Dissolved (   From: Oct-2000   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: STUART PHARMACEUTICALS LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Secretary: I.C. INSURANCE HOLDINGS LIMITED - Dissolved (   From: Mar-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: MEDIMMUNE LIMITED - Active (   From: Sep-2006   To: Oct-2007  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO. 13) LIMITED - Dissolved (   From: Jul-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO. 11) LIMITED - Dissolved (   From: Oct-2000   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Secretary: ASTRAZENECA PLC - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA NOMINEES LIMITED - Active (   From: Nov-2004   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA INVESTMENTS LIMITED - Active (   From: Dec-2004   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ZENECA FINANCE (NETHERLANDS) COMPANY - Active (   From: Oct-2013  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENECA FINANCE (NETHERLANDS) COMPANY - Active (   From: Nov-2004   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ASTRAZENECA FINANCE LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: ASTRAZENECA FINANCE LIMITED - Active (   From: Aug-2000   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENECA HOLDINGS LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENECA BIOSCIENCE LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ASTRAZENECA PENSIONS TRUSTEE LIMITED - Active (   From: May-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: R&Q BETA COMPANY PLC - Converted / closed (   From: Nov-2000   To: Jan-2007  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO 6) LIMITED - Dissolved (   From: Oct-2000   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA QUEST LIMITED - Active (   From: Nov-1999   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENECA LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO. 8) LIMITED - Active (   From: Sep-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO. 9) LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: ASTRAZENECA TREASURY LIMITED - Active (   From: Jan-2009   To: Nov-2014  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ASTRAZENECA EMPLOYEE SHARE TRUST LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA EMPLOYEE SHARE TRUST LIMITED - Active (   From: Nov-1999   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ASTRAZENECA SHARE TRUST LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA SHARE TRUST LIMITED - Active (   From: Nov-1999   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: CAMBRIDGE ANTIBODY TECHNOLOGY GROUP LIMITED - Active (   From: Jun-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: CAMBRIDGE ANTIBODY TECHNOLOGY GROUP LIMITED - Active (   From: Jan-2009   To: Mar-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: WILMINGTON PHARMACEUTICALS LIMITED - Dissolved (   From: Apr-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: KUDOS PHARMACEUTICALS LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: KUDOS PHARMACEUTICALS LIMITED - Active (   From: Jan-2006   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: KUDOS HORSHAM LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: KUDOS HORSHAM LIMITED - Active (   From: Jan-2006   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ARROW THERAPEUTICS LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Secretary: ASTRAZENECA UK LIMITED - Active (   From: Jan-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA JAPAN LIMITED - Active (   From: Sep-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA CHINA UK LIMITED - Active (   From: Sep-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 1 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 2 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 3 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 9 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 4 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: APTIUM CANCER CARE LIMITED - Dissolved (   From: May-2010  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: APTIUM CANCER CARE LIMITED - Dissolved (   From: Jan-2001   To: Jul-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 6 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ASTRAZENECA DEATH IN SERVICE TRUSTEE LIMITED - Active (   From: Sep-2010  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA DEATH IN SERVICE TRUSTEE LIMITED - Active (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 8 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AYZEE 10 LIMITED - Dissolved (   From: Jan-2001   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ASTRAZENECA US INVESTMENTS LIMITED - Active (   From: Apr-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA US INVESTMENTS LIMITED - Active (   From: May-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: TAGRED LIMITED - Dissolved (   From: Sep-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: TAGRED LIMITED - Dissolved (   From: Sep-2006   To: Dec-2007  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Secretary: ASTRAZENECA SWEDEN INVESTMENTS LIMITED - Active (   From: Apr-2003   To: Nov-2006  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ARDEA BIOSCIENCES LIMITED - Active (   From: Jun-2012  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: ALPHACORE PHARMA LIMITED - Dissolved (   From: Jun-2013  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: MERONEM GROUP LIMITED - Dissolved (   From: Dec-2014  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: AZENCO2 LIMITED - Active (   From: Jan-2015  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ENTASIS THERAPEUTICS LIMITED - Active (   From: Mar-2015   To: May-2015  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: CENTUS BIOTHERAPEUTICS LIMITED - Liquidation (   From: Jul-2015   To: Dec-2015  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: AZENCO4 LIMITED - Active (   From: Jan-2016  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT