Resigned Director: ASTRA PHARMACEUTICALS LIMITED - Active (   From: Mar-2001   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: R&Q ALPHA COMPANY PLC - Converted / closed (   From: Nov-2014   To: Sep-2015  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAPHARM - Active (   From: Nov-2000   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Current Director: I.C. INSURANCE HOLDINGS LIMITED - Dissolved (   From: Nov-2014  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: I.C. INSURANCE HOLDINGS LIMITED - Dissolved (   From: Mar-2013   To: Aug-2014  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA NOMINEES LIMITED - Active (   From: Dec-1999   To: Nov-2004  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENECA FINANCE (NETHERLANDS) COMPANY - Active (   From: Dec-1999   To: Nov-2004  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA FINANCE LIMITED - Active (   From: Jun-2012   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA PENSIONS TRUSTEE LIMITED - Active (   From: Mar-2002   To: Jun-2009  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: R&Q BETA COMPANY PLC - Converted / closed (   From: Apr-2010   To: Jun-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ZENCO (NO. 8) LIMITED - Active (   From: Aug-2000   To: Nov-2004  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA TREASURY LIMITED - Active (   From: Sep-2006   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: CAMBRIDGE ANTIBODY TECHNOLOGY GROUP LIMITED - Active (   From: Jun-2006   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: KUDOS PHARMACEUTICALS LIMITED - Active (   From: Jan-2006   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: KUDOS HORSHAM LIMITED - Active (   From: Jan-2006   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ARROW THERAPEUTICS LIMITED - Active (   From: Feb-2007   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA UK LIMITED - Active (   From: May-2013   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA JAPAN LIMITED - Active (   From: Jun-2000   To: Sep-2003  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA CHINA UK LIMITED - Active (   From: Jun-2000   To: Sep-2003  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA SWEDEN INVESTMENTS LIMITED - Active (   From: Sep-2006   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: ASTRAZENECA INTERMEDIATE HOLDINGS LIMITED - Active (   From: Jan-2012   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: MERONEM GROUP LIMITED - Dissolved (   From: Dec-2014   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AZENCO2 LIMITED - Active (   From: Jan-2015   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: CENTUS BIOTHERAPEUTICS LIMITED - Liquidation (   From: Jul-2015   To: Dec-2015  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT

Resigned Director: AZENCO4 LIMITED - Active (   From: Jan-2016   To: May-2017  )

Address: C/O DELOITTE LLP, PO BOX 500 2 HARDMAN STREET, MANCHESTER, M60 2AT